http://jbiol.com/content/6/1/2/comments The latest comments on the article 'Dosage compensation is less effective in birds than in mammals' 2007-04-05T14:52:29Z http://jbiol.com/content/6/1/2/comments#272537 <p>Dr Itoh et al's paper, while interesting in its specific detail, has not grasped the basis of gene dosage. I recommend the authors reconsider this basis by consulting two early papers in TBMM (Theoretical Biology and Medical Modelling), which is a BMC journal. The references are to John W Porteous' papers:</p><p>TBMM 1, 4, 2004</p><p>TBMM 1, 6, 2004</p><p>both of which are discussion on the meaning of Mendelian "genetics" (traits) when considered in the light of Kacser's Metabolic Regulation Hypothesis. Gene dosage is best understood only when levels of enzymes (or their products) approach a rate-limiting level within any metabolic (biocheical) pathway.</p> Denys Wheatley 2007-04-05T14:52:29Z http://jbiol.com/content/6/1/2 Itoh et al. Journal of Biology 6 2 Thu Mar 22 00:00:00 GMT 2007