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Robust and specific inhibition of microRNAs in Caenorhabditis elegans

Samrat T Kundu and Frank J Slack*

Author Affiliations

Department of Molecular, Cellular and Development Biology, Yale University, New Haven, CT 06520, USA

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Journal of Biology 2010, 9:20  doi:10.1186/jbiol230

Published: 1 April 2010


MicroRNAs (miRNAs) are small non-coding RNAs that regulate the expression of numerous target genes. Yet, while hundreds of miRNAs have been identified, little is known about their functions. In a recent report published in Silence, Zheng and colleagues demonstrate a technique for robust and specific knockdown of miRNA expression in Caenorhabditis elegans using modified antisense oligonucleotides, which could be utilized as a powerful tool for the study of regulation and function of miRNAs in vivo.

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