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Acoel and platyhelminth models for stem-cell research

Alexandra E Bely1 and James M Sikes2

Author Affiliations

1 Biology Department, University of Maryland, College Park, MD 20742, USA

2 Department of Cell and Developmental Biology, University of Illinois at Urbana-Champaign, 601 South Goodwin Avenue, Urbana, IL 61801, USA

Journal of Biology 2010, 9:14  doi:10.1186/jbiol223

Published: 16 February 2010


Acoel and platyhelminth worms are particularly attractive invertebrate models for stem-cell research because their bodies are continually renewed from large pools of somatic stem cells. Several recent studies, including one in BMC Developmental Biology, are beginning to reveal the cellular dynamics and molecular basis of stem-cell function in these animals.

See research article webcite.