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The THO complex as a key mRNP biogenesis factor in development and cell differentiation

Sonia Jimeno and Andrés Aguilera*

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Centro Andaluz de Biología Molecular y Medicina Regenerativa, Av. Américo Vespucio s/n, 41092 Sevilla, Spain

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Citation and License

Journal of Biology 2010, 9:6  doi:10.1186/jbiol217

Published: 28 January 2010


The THO complex is a key component in the co-transcriptional formation of messenger ribonucleoparticles that are competent to be exported from the nucleus, yet its precise function is unknown. A recent study in BMC Biology on the role of the THOC5 subunit in cell physiology and mouse development provides new clues to the role of the THO complex in cell differentiation.

See research article webcite.