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Physical forces in myelination and repair: a question of balance?

Nina G Bauer* and Charles ffrench-Constant

Author Affiliations

MRC Centre for Regenerative Medicine, Centre for Multiple Sclerosis Research, The University of Edinburgh, Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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Journal of Biology 2009, 8:78  doi:10.1186/jbiol169

Published: 25 September 2009


A recent report in BMC Cell Biology examines how the balance of extracellular forces and intracellular contractions regulate the shape changes required for oligodendrocyte myelination. A failure of remyelination such as seen in multiple sclerosis could be caused by loss of this balance.

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