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The where and wherefore of evolutionary breakpoints

David Sankoff

Author affiliations

Department of Mathematics and Statistics, University of Ottawa, 585 King Edward Avenue, Ottawa K1N 6N5, Canada

Citation and License

Journal of Biology 2009, 8:66  doi:10.1186/jbiol162

Published: 24 July 2009


The 'action' in genome-level evolution lies not in the large gene-containing segments that are conserved among related species, but in the breakpoint regions between these segments. Two recent papers in BMC Genomics detail the pattern of repetitive elements associated with breakpoints and the epigenetic conditions under which breakage occurs.