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Comparative embryology without a microscope: using genomic approaches to understand the evolution of development

David A Garfield and Gregory A Wray

Author Affiliations

Biology Department and Institute for Genome Science & Policy, Duke University, Durham, NC 27708, USA

Journal of Biology 2009, 8:65  doi:10.1186/jbiol161

Published: 21 July 2009


Until recently, understanding developmental conservation and change has relied on embryological comparisons and analyses of single genes. Several studies, including one recently published in BMC Biology, have now taken a genomic approach to this classical problem, providing insights into how selection operates differentially across the life cycle.