Email updates

Keep up to date with the latest news and content from Journal of Biology and BioMed Central.

Open Badges Minireview

Oxidative stress, thermogenesis and evolution of uncoupling proteins

Eduardo Rial1* and Rafael Zardoya2

Author Affiliations

1 Centro de Investigaciones Biológicas, CSIC, Ramiro de Maezu 9, 28040 Madrid, Spain

2 Museo Nacional de Ciencias Naturales, CSIC, Gutiérrez Abascal 2, 28006 Madrid, Spain

For all author emails, please log on.

Journal of Biology 2009, 8:58  doi:10.1186/jbiol155

Published: 16 June 2009


The uncoupling protein UCP1 provides eutherian mammals with an efficient thermogenic mechanism. Recent work published in BMC Evolutionary Biology, following the identification of UCP1 orthologs in non-eutherians, concludes that this unique function appeared after sequence divergence and purifying selection that allowed functional co-option.