Can modular analysis identify disease-associated candidate genes for therapeutics?
Department of Medicine, Center for Molecular Medicine, Karolinska University Hospital, 171 76 Solna, Stockholm, Sweden
Journal of Biology 2009, 8:48 doi:10.1186/jbiol149Published: 28 May 2009
Complex diseases such as allergy change gene expression in several cell types and tissues. Benson and colleagues have now shown, in a paper in BMC Systems Biology, that this complexity can be studied effectively using an integrated experimental and computational modular analysis. Their strategy revealed a core of allergy-associated genes of potential therapeutic value.