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Can modular analysis identify disease-associated candidate genes for therapeutics?

Jesper Tegnér

Author Affiliations

Department of Medicine, Center for Molecular Medicine, Karolinska University Hospital, 171 76 Solna, Stockholm, Sweden

Journal of Biology 2009, 8:48  doi:10.1186/jbiol149

Published: 28 May 2009


Complex diseases such as allergy change gene expression in several cell types and tissues. Benson and colleagues have now shown, in a paper in BMC Systems Biology, that this complexity can be studied effectively using an integrated experimental and computational modular analysis. Their strategy revealed a core of allergy-associated genes of potential therapeutic value.