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Reconstructing prokaryotic transcriptional regulatory networks: lessons from actinobacteria

Thiago M Venancio and L Aravind*

Author Affiliations

National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20894, USA

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Journal of Biology 2009, 8:29  doi:10.1186/jbiol132

Published: 15 April 2009


Reconstruction of transcriptional regulatory networks of uncharacterized bacteria is a main challenge for the post-genomic era. Recent studies, including one in BMC Systems Biology, address this problem in the relatively underexplored actinobacteria clade, which includes major pathogenic and economically relevant taxa.