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Liaison amid disorder: non-native interactions may underpin long-range coupling in proteins

Hue Sun Chan* and Zhuqing Zhang

Author Affiliations

Department of Biochemistry, Department of Molecular Genetics, and Department of Physics, University of Toronto, 1 King's College Circle, MSB 5207, Toronto, Ontario, M5S 1A8 Canada

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Journal of Biology 2009, 8:27  doi:10.1186/jbiol126

Published: 13 March 2009


A lattice-model study of double-mutant cycles published in BMC Structural Biology underscores how interactions in non-native conformations can lead to thermodynamic coupling between distant residues in globular proteins, adding to recent advances in delineating the often crucial roles played by disordered conformational ensembles in protein behavior.