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Scribble at the crossroads

Sandrine Etienne-Manneville

Author affiliations

Institut Pasteur, Cell Polarity and Migration Group and CNRS URA 2582, 25 rue du Dr Roux, 75724 Paris cedex 15, France

Citation and License

Journal of Biology 2009, 8:104  doi:10.1186/jbiol190

Published: 29 December 2009


Although proteins involved in determining apical-basal cell polarity have been directly linked to tumorigenesis, their precise roles in this process remain unclear. A recent report in BMC Biology clarifies the signaling pathways that control cell polarity, proliferation and apoptosis downstream of the tumor suppressor and apical-basal polarity determinant Scribble.

See research article webcite.