Email updates

Keep up to date with the latest news and content from Journal of Biology and BioMed Central.

Highly Accessed Open Badges Minireview

Adaptations of proteins to cellular and subcellular pH

Bertrand Garcia-Moreno

Author Affiliations

Department of Biophysics, Johns Hopkins University, Baltimore, MD 21218, USA

Journal of Biology 2009, 8:98  doi:10.1186/jbiol199

Published: 2 December 2009


Bioinformatics-based searches for correlations between subcellular localization and pI or charge distribution of proteins have failed to detect meaningful correlations. Recent work published in BMC Biology finds that a physicochemical metric of charge distribution correlates better with subcellular pH than does pI.

See research article webcite