Adaptations of proteins to cellular and subcellular pH
Department of Biophysics, Johns Hopkins University, Baltimore, MD 21218, USA
Journal of Biology 2009, 8:98 doi:10.1186/jbiol199Published: 2 December 2009
Bioinformatics-based searches for correlations between subcellular localization and pI or charge distribution of proteins have failed to detect meaningful correlations. Recent work published in BMC Biology finds that a physicochemical metric of charge distribution correlates better with subcellular pH than does pI.