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Chromatin 'programming' by sequence - is there more to the nucleosome code than %GC?

Amanda Hughes and Oliver J Rando*

Author Affiliations

Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 364 Plantation Street No. 903, Worcester, MA 01605, USA

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Journal of Biology 2009, 8:96  doi:10.1186/jbiol207

Published: 23 December 2009


The role of genomic sequence in directing the packaging of eukaryotic genomes into chromatin has been the subject of considerable recent debate. A new paper from Tillo and Hughes shows that the intrinsic thermodynamic preference of a given sequence in the yeast genome for the histone octamer can largely be captured with a simple model, and in fact is mostly explained by %GC. Thus, the rules for predicting nucleosome occupancy from genomic sequence are much less complicated than has been claimed.

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