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Life and death as a T lymphocyte: from immune protection to HIV pathogenesis

Nienke Vrisekoop, Judith N Mandl and Ronald N Germain*

Author Affiliations

Lymphocyte Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 10 Center Dr MSC-1892, Bethesda, MD, USA

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Journal of Biology 2009, 8:91  doi:10.1186/jbiol198

Published: 27 November 2009


Detailed analysis of T cell dynamics in humans is challenging and mouse models can be important tools for characterizing T cell dynamic processes. In a paper just published in Journal of Biology, Marques et al. suggest that a mouse model with its activated CD4+ T cells are deleted has relevance for HIV infection.

See research article webcite