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Guanylyl cyclase sees the light

John JG Tesmer

Author Affiliations

Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109-2216, USA and the Department of Pharmacology, University of Michigan, Ann Arbor, MI 48109-5632, USA

Journal of Biology 2008, 7:31  doi:10.1186/jbiol96

Published: 31 October 2008


Cyclic guanosine monophosphate (cGMP) is a critical second messenger that regulates cardiovascular function and vision in humans. Two recent papers, including one in BMC Structural Biology, have revealed atomic structures of the enzymes that catalyze the synthesis of cGMP providing new clues about the molecular basis of substrate specificity and allosteric regulation in nucleotide cyclases.