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NFIX – one gene, two knockouts, multiple effects

Vladimir Pekarik1 and Juan Carlos Izpisua Belmonte12*

Author affiliations

1 Center of Regenerative Medicine in Barcelona, Doctor Aiguader 88, 08003 Barcelona, Spain

2 Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA

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Citation and License

Journal of Biology 2008, 7:29  doi:10.1186/jbiol94

Published: 23 October 2008


A previous knockout of the transcription factor gene nuclear factor IX (NFIX) in mice produced impaired development of the corpus callosum and severe skeletal defects. A recent paper in BMC Developmental Biology reports an apparently similar NFIX knockout that produced marked differences in phenotype, raising intriguing general questions about the possible causes of such differences in mouse knockouts.