Email updates

Keep up to date with the latest news and content from Journal of Biology and BioMed Central.

Highly Accessed Open Badges Minireview

Bridging spinal cord injuries

James W Fawcett

Author Affiliations

Cambridge University Centre for Brain Repair, Robinson Way, Cambridge CB2 0PY, UK

Journal of Biology 2008, 7:25  doi:10.1186/jbiol89

Published: 15 October 2008


One strategy for spinal cord injury repair is to make cellular bridges that support axon regeneration. However, the bridging cells often fail to integrate with host tissue and may lead to increased pain sensitivity. Recent work has tested bridging with two forms of progenitor-derived astrocyte. One type integrates, suppresses scar formation and promotes axon regeneration, whereas another very similar type, reported in Journal of Biology, does not support regeneration and increases pain sensitivity.