Adapted from Byrne et al. , a superimposed network composed of different types of functional linkages contains subnetworks of genes that are highly interconnected based on one type of data: coexpression (blue), co-phenotype (green), or eukaryotic protein-protein interactions ('interolog'; purple). Byrne et al. found that these subnetworks were bridged by genetic interactions (pink) more often than expected by chance. Many such subnetworks were enriched for genes with shared functional annotations, supporting the idea that enhancing genetic interactions (identified by reduced function of a pair of genes) tend to bridge distinct functional modules.
Gunsalus Journal of Biology 2008 7:8 doi:10.1186/jbiol70