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Imp-L2, a putative homolog of vertebrate IGF-binding protein 7, counteracts insulin signaling in Drosophila and is essential for starvation resistance

Basil Honegger1, Milos Galic13, Katja Köhler2, Franz Wittwer1, Walter Brogiolo1, Ernst Hafen2* and Hugo Stocker2

Author Affiliations

1 Zoological Institute, University of Zürich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland

2 Institute for Molecular Systems Biology (IMSB), ETH Zürich, Wolfgang-Pauli-Strasse 16, CH-8093 Zürich, Switzerland

3 Current address: Chemical and Systems Biology, 318 Campus Drive, Clark Building W200, Stanford University Medical Center, Stanford, CA 94305-5174, USA

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Journal of Biology 2008, 7:10  doi:10.1186/jbiol72

Published: 15 April 2008

Additional files

Additional data file 1:

Figure S1 shows that the over-expression of Imp-L2 results in reduced PIP3 levels in vivo. In Figure S2, the dynamic expression pattern of Imp-L2 during development is shown. Figure S3 demonstrates that a reduction in Dilp levels enhances the growth-inhibitory effect of Imp-L2.

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