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Functions of O-fucosyltransferase in Notch trafficking and signaling: towards the end of a controversy?

Nicolas Vodovar12 and François Schweisguth12*

Author Affiliations

1 Ecole Normale Supérieure, CNRS UMR8542, 46 rue d'Ulm, 75005 Paris, France.

2 Institut Pasteur, CNRS URA2578, 25 rue du Dr Roux, 75015 Paris, France.

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Journal of Biology 2008, 7:7  doi:10.1186/jbiol68

Published: 28 February 2008


The precise role of the O-fucosyltransferase Ofut1 in Notch-receptor trafficking has remained controversial. A recent study sheds new light on the non-catalytic activity of Ofut1 and provides further evidence that Ofut1 acts as a chaperone in the endoplasmic reticulum.