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A bridge to transcription by RNA polymerase

Craig D Kaplan and Roger D Kornberg*

Author Affiliations

Department of Structural Biology, Stanford University, 299 Campus Dr. West, Stanford, CA 94305, USA

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Journal of Biology 2008, 7:39  doi:10.1186/jbiol99

Published: 2 December 2008


A comprehensive survey of single amino-acid substitution mutations critical for RNA polymerase function published in Journal of Biology supports a proposed mechanism for polymerase action in which movement of the polymerase 'bridge helix' promotes transcriptional activity in cooperation with a critical substrate-interaction domain, the 'trigger loop'.