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The long term effects of chemotherapy on the central nervous system

Patricia K Duffner

Author Affiliations

Department of Neurology, Women and Children's Hospital of Buffalo, University of Buffalo School of Medicine, 219 Bryant St., Buffalo, NY 14222, USA

Journal of Biology 2006, 5:21  doi:10.1186/jbiol51

Published: 30 November 2006


Cranial radiotherapy is known to have adverse effects on intelligence. A new study shows that chemotherapy is also toxic to the central nervous system, especially to neural progenitor cells and oligodendrocytes. By identifying the cell populations at risk, these results may help explain the neurological problems previously seen after chemotherapy.