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A balancing act between the X chromosome and the autosomes

Mimi K Cheng and Christine M Disteche*

Author Affiliations

Departments of Pathology and Medicine, University of Washington, Seattle, WA 98195, USA

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Journal of Biology 2006, 5:2  doi:10.1186/jbiol32

Published: 16 February 2006


Dosage compensation equalizes gene dosage between males and females, but its role in balancing expression between the X chromosome and the autosomes may be far more important. Now, DNA microarrays have shown equality between the average expression of X-linked genes and that of autosomal genes, in male and female tissues of flies, worms and mice.