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Movement in ribosome translocation

Christopher S Fraser1 and John WB Hershey2*

Author Affiliations

1 Department of Molecular and Cell Biology, Howard Hughes Medical Institute, University of California, Berkeley, CA 947020, USA

2 Department of Biochemistry and Molecular Medicine, School of Medicine, University of California, Davis, CA 95616, USA

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Journal of Biology 2005, 4:8  doi:10.1186/jbiol27

Published: 27 June 2005


Translocation of peptidyl-tRNA and mRNA within the ribosome during protein synthesis is promoted by the elongation factor EF-G and by the hydrolysis of GTP. A new study reports that EF-G binds to ribosomes as an EF-G•GDP complex and that GTP is exchanged for GDP on the ribosome. Together with cryo-electron microscopy, this unexpected finding helps clarify the role of GTP in translocation.