Four-node network motifs corresponding to the 'compensatory complexes/processes' theme. (a) A schematic diagram unifying the collection of four-node motifs corresponding to the 'compensatory complexes/processes' theme; (b) examples of specific four-node motifs together with the motif statistics; (c) a specific example of a four-node subgraph matching a few of these motifs; (d) the larger structure corresponding to the network theme. Each colored link represents one of the four interaction types according to the color scheme (see key). For a given motif, Nreal is the number of corresponding subgraphs in the real network, and Nrand describes the number of corresponding subgraphs in a randomized network, represented by the average and the standard deviation.
Zhang et al. Journal of Biology 2005 4:6 doi:10.1186/jbiol23