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Untangling the web of functional and physical interactions in yeast

Markus J Herrgård and Bernhard Ø Palsson*

Author Affiliations

Department of Bioengineering, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0412, USA

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Journal of Biology 2005, 4:5  doi:10.1186/jbiol26

Published: 8 June 2005


An analysis of an integrated network of over 150,000 functional and physical interactions in yeast suggests that the network can be hierarchically decomposed into themes and thematic maps. This decomposition can be used to explore the organizational principles of integrated biological networks within cells.