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All systems GO for understanding mouse gene function

Chris Holmes12 and Steve DM Brown1*

Author Affiliations

1 MRC Mammalian Genetics Unit, Harwell OX11 0RD, UK

2 Department of Statistics, Oxford Centre for Gene Function, University of Oxford, 1 South Parks Road, Oxford OX1 3TG, UK

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Journal of Biology 2004, 3:20  doi:10.1186/jbiol19

Published: 17 December 2004


It is widely supposed that the tissue specificity of gene expression indicates gene function. Now, an extensive analysis of gene expression in the mouse reveals that quantitative measurement of expression levels in different tissues can contribute powerfully to the prediction of gene function.