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Hide and seek: the secret identity of the phosphatidylserine receptor

Patrick Williamson1* and Robert A Schlegel2

Author Affiliations

1 Department of Biology, Amherst College, Amherst, MA 01002, USA

2 Department of Biochemistry and Molecular Biology, Penn State University, University Park, PA 16802, USA

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Journal of Biology 2004, 3:14  doi:10.1186/jbiol14

Published: 23 September 2004


Phosphatidylserine on the dying cell surface helps identify apoptotic cells to phagocytes, which then engulf them. A candidate phagocyte receptor for phosphatidylserine was identified using phage display, but the phenotypes of knockout mice lacking this presumptive receptor, as well as the location of the protein within cells, cast doubt on the assignment of this protein as the phosphatidylserine receptor.