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Shrinkage control: regulation of insulin-mediated growth by FOXO transcription factors

Thomas P Neufeld

Author Affiliations

Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455, USA

Journal of Biology 2003, 2:18  doi:10.1186/1475-4924-2-18

Published: 11 September 2003


The insulin signaling pathway regulates organismal growth in response to nutrient conditions by controlling a range of metabolic and biosynthetic processes. Recent studies in Drosophila have shown how transcriptional responses to reduced insulin and nutrient levels can act to inhibit growth.