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Tracking evolution's footprints in the genome

Jonathan B Weitzman

Journal of Biology 2003, 2:9  doi:10.1186/1475-4924-2-9

Published: 23 June 2003


The strategy of using 'phylogenetic footprinting' to find regulatory sites that are conserved between pairs of related complex genomes has led to the development of a suite of computational tools that succeed in finding functionally important transcription-factor-binding sequences.